The MILK Fund grew out of the Hope Fund, which was started under the umbrella of the Catholic Welfare Services in the 90s. It was chaired by Dr Ee Peng Liang; and later by President Wee Kim Wee. 

The Hope Fund was set up to help children and young persons access medical treatment for chronic illnesses. Its aim was to ensure that all children with chronic but treatable illnesses were given the opportunity to live a normal life as contributing citizens. As the work of Hope Fund progressed, it was clear that making a difference to the lives of these children went far beyond just medical treatment. Having a chronically-ill child impacts the whole family, in particular, their siblings. 

MILK was initiated to more holistically address the needs of these children. MILK was subsequently registered in 2004.